Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 25, median = 18 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 2.85, hr = 0.33 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 |
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The overall error was 0.056.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.012 0.034 0.004 0.006
The overall power was 0.798.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.480 0.326 0.240 0.264
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 6 | 5 | 1 | 1 |
| futility | 0 | 0 | 0 | 1 | 1 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 276 (245, 318) | 181 (121, 251) | 235 (173, 292) | 246 (183, 291) | 247 (185, 292) | |
| n_unique | 252 (223, 291) | 164 (109, 231) | 215 (156, 264) | 224 (166, 268) | 225 (167, 266) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 4 (4, 5) | 6 (4, 7) | 5 (5, 5) | 4 (4, 5) | |
| post_p | NA (NA, NA) | 0.57 (0.04, 0.98) | 0.58 (0.05, 0.96) | 0.29 (0.02, 0.78) | 0.22 (0.02, 0.7) | |
| rate | 0.094 (0.085, 0.104) | 0.09 (0.074, 0.112) | 0.091 (0.079, 0.109) | 0.1 (0.089, 0.113) | 0.101 (0.09, 0.115) | |
| TP53- & AR- | graduation | 0 | 240 | 0 | 0 | 1 |
| futility | 0 | 1 | 118 | 138 | 119 | |
| max_n | 0 | 3 | 17 | 15 | 23 | |
| n | 116 (95, 145) | 77 (26, 116) | 98 (32, 130) | 97 (31, 132) | 99 (29, 135) | |
| n_unique | 108 (87, 135) | 72 (24, 105) | 89 (29, 118) | 89 (29, 122) | 91 (27, 123) | |
| time_trial | 36 (36, 36) | 36 (10, 36) | 36 (13, 36) | 36 (12, 36) | 36 (12, 36) | |
| time_stop | NA (NA, NA) | 13 (9, 29) | 14 (9, 27) | 14 (9, 23) | 13 (9, 20) | |
| post_p | NA (NA, NA) | 1 (0.93, 1) | 0.02 (0, 0.18) | 0.03 (0, 0.26) | 0.03 (0, 0.24) | |
| rate | 0.073 (0.063, 0.086) | 0.043 (0.034, 0.052) | 0.109 (0.091, 0.134) | 0.105 (0.088, 0.134) | 0.105 (0.089, 0.132) | |
| TP53+ | graduation | 0 | 1 | 16 | 1 | 1 |
| futility | 0 | 237 | 1 | 0 | 4 | |
| max_n | 0 | 0 | 8 | 17 | 11 | |
| n | 119 (103, 143) | 87 (29, 119) | 108 (76, 133) | 115 (94, 138) | 114 (94, 136) | |
| n_unique | 108 (94, 131) | 78 (27, 107) | 98 (68, 120) | 104 (85, 125) | 103 (84, 123) | |
| time_trial | 36 (36, 36) | 36 (11, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 17 (9, 32) | 11 (8, 18) | 9 (9, 9) | 10 (10, 16) | |
| post_p | NA (NA, NA) | 0.02 (0, 0.16) | 0.97 (0.61, 1) | 0.72 (0.22, 0.97) | 0.66 (0.21, 0.96) | |
| rate | 0.113 (0.097, 0.131) | 0.159 (0.138, 0.197) | 0.084 (0.068, 0.103) | 0.103 (0.086, 0.122) | 0.105 (0.089, 0.123) | |
| DRD+ | graduation | 0 | 0 | 1 | 120 | 132 |
| futility | 0 | 116 | 10 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 80 (65, 99) | 49 (28, 77) | 67 (43, 91) | 69 (33, 91) | 68 (32, 89) | |
| n_unique | 74 (59, 92) | 44 (25, 68) | 59 (38, 81) | 62 (29, 81) | 61 (30, 81) | |
| time_trial | 36 (36, 36) | 36 (18, 36) | 36 (36, 36) | 36 (19, 36) | 36 (18, 36) | |
| time_stop | NA (NA, NA) | 19 (13, 26) | 16 (13, 23) | 22 (13, 33) | 21 (13, 33) | |
| post_p | NA (NA, NA) | 0.21 (0.02, 0.71) | 0.57 (0.12, 0.94) | 1 (0.99, 1) | 1 (0.99, 1) | |
| rate | 0.091 (0.074, 0.111) | 0.098 (0.073, 0.129) | 0.078 (0.062, 0.1) | 0.036 (0.027, 0.045) | 0.037 (0.028, 0.045) | |
| TEfus+ | graduation | 0 | 0 | 163 | 0 | 1 |
| futility | 0 | 107 | 0 | 14 | 13 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 105 (87, 128) | 69 (34, 99) | 86 (27, 112) | 94 (72, 117) | 94 (69, 118) | |
| n_unique | 96 (79, 118) | 61 (30, 89) | 77 (25, 101) | 85 (65, 105) | 85 (62, 107) | |
| time_trial | 36 (36, 36) | 36 (16, 36) | 36 (12, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 16 (11, 33) | 15 (9, 31) | 16 (13, 28) | 14 (11, 25) | |
| post_p | NA (NA, NA) | 0.03 (0, 0.3) | 1 (0.98, 1) | 0.18 (0.01, 0.62) | 0.14 (0.01, 0.58) | |
| rate | 0.074 (0.062, 0.088) | 0.108 (0.083, 0.136) | 0.038 (0.03, 0.046) | 0.086 (0.072, 0.107) | 0.089 (0.074, 0.109) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 247 | 123 | 140 | 122 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 17 | 15 | 23 | |
| n | 70 (55, 89) | 50 (16, 73) | 62 (20, 83) | 60 (20, 82) | 60 (20, 84) | |
| n_unique | 64 (50, 85) | 47 (15, 68) | 58 (19, 78) | 56 (19, 77) | 56 (19, 78) | |
| post_p | NA (NA, NA) | 1 (0.95, 1) | 0 (0, 0.06) | 0 (0, 0.06) | 0 (0, 0.07) | |
| rate | 0.083 (0.069, 0.102) | 0.043 (0.033, 0.057) | 0.159 (0.134, 0.194) | 0.161 (0.133, 0.198) | 0.158 (0.132, 0.191) | |
| —+ | graduation | 0 | 318 | 253 | 148 | 130 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 17 | 15 | 23 | |
| n | 15 (9, 22) | 7 (2, 17) | 10 (2, 18) | 12 (4, 19) | 14 (4, 20) | |
| n_unique | 14 (9, 21) | 6 (2, 16) | 9 (2, 16) | 11 (3, 17) | 12 (4, 19) | |
| post_p | NA (NA, NA) | 0.76 (0.38, 0.95) | 0.81 (0.46, 0.98) | 0.06 (0, 0.24) | 0.05 (0, 0.22) | |
| rate | 0.052 (0.031, 0.082) | 0.042 (0.02, 0.089) | 0.038 (0.02, 0.075) | 0.161 (0.111, 0.25) | 0.164 (0.112, 0.242) | |
| –+- | graduation | 0 | 244 | 22 | 3 | 7 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 17 | 11 | |
| n | 38 (29, 48) | 29 (10, 42) | 36 (29, 46) | 37 (29, 46) | 37 (29, 47) | |
| n_unique | 35 (26, 43) | 26 (9, 39) | 34 (26, 42) | 34 (26, 43) | 34 (27, 43) | |
| post_p | NA (NA, NA) | 0.42 (0.1, 0.8) | 0.4 (0.08, 0.81) | 0.43 (0.11, 0.82) | 0.38 (0.07, 0.76) | |
| rate | 0.147 (0.118, 0.184) | 0.164 (0.127, 0.22) | 0.159 (0.126, 0.201) | 0.157 (0.126, 0.199) | 0.164 (0.13, 0.205) | |
| –++ | graduation | 0 | 294 | 181 | 17 | 20 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 17 | 11 | |
| n | 27 (20, 36) | 17 (6, 28) | 22 (8, 31) | 27 (18, 35) | 26 (18, 35) | |
| n_unique | 25 (18, 33) | 16 (6, 26) | 19 (7, 28) | 24 (16, 32) | 24 (16, 32) | |
| post_p | NA (NA, NA) | 0.1 (0.01, 0.35) | 0.99 (0.92, 1) | 0.06 (0, 0.28) | 0.05 (0, 0.26) | |
| rate | 0.087 (0.062, 0.119) | 0.163 (0.117, 0.234) | 0.037 (0.023, 0.056) | 0.158 (0.122, 0.204) | 0.161 (0.123, 0.216) | |
| -+– | graduation | 0 | 333 | 131 | 245 | 235 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 17 | 14 | 21 | |
| n | 15 (10, 22) | 8 (2, 17) | 13 (4, 20) | 10 (3, 19) | 11 (3, 19) | |
| n_unique | 14 (9, 20) | 7 (2, 15) | 12 (4, 18) | 9 (2, 17) | 10 (2, 17) | |
| post_p | NA (NA, NA) | 0.76 (0.4, 0.96) | 0.06 (0, 0.3) | 0.83 (0.46, 0.98) | 0.83 (0.48, 0.98) | |
| rate | 0.083 (0.053, 0.132) | 0.043 (0.019, 0.08) | 0.161 (0.109, 0.243) | 0.036 (0.019, 0.078) | 0.038 (0.02, 0.076) | |
| -+-+ | graduation | 0 | 373 | 259 | 253 | 242 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 3 | 17 | 14 | 21 | |
| n | 16 (10, 22) | 6 (2, 17) | 10 (2, 19) | 11 (3, 20) | 12 (3, 20) | |
| n_unique | 14 (8, 21) | 5 (2, 16) | 9 (2, 17) | 10 (3, 18) | 11 (3, 18) | |
| post_p | NA (NA, NA) | 0.52 (0.25, 0.78) | 0.57 (0.3, 0.84) | 0.59 (0.29, 0.86) | 0.6 (0.32, 0.87) | |
| rate | 0.054 (0.032, 0.086) | 0.043 (0.02, 0.077) | 0.04 (0.019, 0.074) | 0.037 (0.019, 0.071) | 0.038 (0.02, 0.069) | |
| -++- | graduation | 0 | 303 | 33 | 121 | 139 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 15 | 11 | |
| n | 8 (5, 13) | 5 (2, 10) | 8 (4, 12) | 7 (3, 12) | 7 (3, 11) | |
| n_unique | 7 (4, 12) | 4 (1, 9) | 7 (3, 11) | 6 (2, 11) | 6 (2, 10) | |
| post_p | NA (NA, NA) | 0.29 (0.12, 0.55) | 0.26 (0.06, 0.54) | 0.89 (0.67, 0.98) | 0.9 (0.65, 0.98) | |
| rate | 0.15 (0.092, 0.263) | 0.171 (0.089, 0.356) | 0.16 (0.096, 0.278) | 0.035 (0.012, 0.07) | 0.035 (0.012, 0.074) | |
| -+++ | graduation | 0 | 336 | 190 | 135 | 151 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 15 | 11 | |
| n | 8 (4, 13) | 5 (1, 9) | 6 (2, 12) | 8 (3, 12) | 7 (2, 12) | |
| n_unique | 7 (4, 12) | 4 (1, 8) | 5 (1, 11) | 7 (2, 11) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.21 (0.05, 0.39) | 0.7 (0.43, 0.9) | 0.69 (0.43, 0.92) | 0.72 (0.45, 0.92) | |
| rate | 0.091 (0.045, 0.179) | 0.169 (0.095, 0.391) | 0.037 (0.014, 0.08) | 0.036 (0.016, 0.073) | 0.034 (0.013, 0.072) | |
| +— | graduation | 0 | 6 | 5 | 2 | 2 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (7, 17) | 12 (7, 17) | 12 (8, 17) | 12 (8, 17) | 12 (7, 17) | |
| n_unique | 10 (7, 15) | 11 (6, 15) | 11 (7, 15) | 10 (6, 15) | 11 (6, 16) | |
| post_p | NA (NA, NA) | 0.47 (0.16, 0.8) | 0.46 (0.14, 0.82) | 0.45 (0.16, 0.82) | 0.47 (0.17, 0.79) | |
| rate | 0.149 (0.095, 0.233) | 0.159 (0.11, 0.244) | 0.162 (0.106, 0.255) | 0.163 (0.108, 0.245) | 0.16 (0.108, 0.236) | |
| +–+ | graduation | 0 | 113 | 168 | 16 | 16 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 10 (6, 15) | 9 (4, 14) | 8 (3, 14) | 10 (6, 15) | 10 (6, 15) | |
| n_unique | 9 (5, 14) | 8 (3, 13) | 8 (3, 13) | 9 (5, 13) | 9 (5, 14) | |
| post_p | NA (NA, NA) | 0.23 (0.06, 0.51) | 0.94 (0.73, 0.99) | 0.23 (0.06, 0.51) | 0.21 (0.05, 0.52) | |
| rate | 0.088 (0.048, 0.156) | 0.169 (0.107, 0.274) | 0.039 (0.016, 0.067) | 0.162 (0.107, 0.256) | 0.167 (0.105, 0.261) | |
| +-+- | graduation | 0 | 244 | 22 | 3 | 7 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 17 | 11 | |
| n | 10 (6, 14) | 7 (2, 13) | 10 (6, 15) | 10 (6, 14) | 10 (6, 15) | |
| n_unique | 9 (5, 13) | 6 (2, 12) | 9 (5, 14) | 9 (5, 13) | 9 (5, 14) | |
| post_p | NA (NA, NA) | 0.44 (0.18, 0.78) | 0.47 (0.13, 0.8) | 0.49 (0.18, 0.81) | 0.49 (0.19, 0.8) | |
| rate | 0.153 (0.093, 0.238) | 0.175 (0.108, 0.368) | 0.166 (0.105, 0.27) | 0.159 (0.102, 0.249) | 0.16 (0.103, 0.244) | |
| +-++ | graduation | 0 | 294 | 181 | 17 | 20 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 17 | 11 | |
| n | 11 (7, 17) | 7 (2, 13) | 9 (3, 14) | 10 (6, 16) | 10 (6, 16) | |
| n_unique | 10 (6, 15) | 6 (2, 12) | 8 (2, 13) | 9 (5, 15) | 9 (5, 15) | |
| post_p | NA (NA, NA) | 0.26 (0.07, 0.53) | 0.93 (0.67, 0.99) | 0.2 (0.04, 0.5) | 0.2 (0.04, 0.46) | |
| rate | 0.087 (0.049, 0.148) | 0.168 (0.102, 0.36) | 0.04 (0.017, 0.08) | 0.158 (0.108, 0.264) | 0.164 (0.11, 0.26) | |
| ++– | graduation | 0 | 122 | 16 | 122 | 134 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (4, 12) | 6 (2, 11) | 7 (4, 12) | 7 (3, 12) | 7 (3, 11) | |
| n_unique | 7 (4, 11) | 6 (2, 10) | 7 (3, 11) | 6 (3, 10) | 6 (2, 10) | |
| post_p | NA (NA, NA) | 0.28 (0.09, 0.51) | 0.25 (0.08, 0.52) | 0.89 (0.65, 0.99) | 0.89 (0.64, 0.98) | |
| rate | 0.153 (0.091, 0.258) | 0.165 (0.104, 0.307) | 0.162 (0.094, 0.296) | 0.036 (0.013, 0.07) | 0.036 (0.013, 0.074) | |
| ++-+ | graduation | 0 | 191 | 177 | 136 | 147 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (4, 13) | 6 (2, 11) | 6 (2, 11) | 7 (3, 12) | 7 (3, 11) | |
| n_unique | 7 (4, 12) | 6 (2, 10) | 6 (2, 10) | 6 (2, 11) | 6 (2, 10) | |
| post_p | NA (NA, NA) | 0.17 (0.04, 0.37) | 0.7 (0.43, 0.9) | 0.74 (0.47, 0.92) | 0.74 (0.48, 0.91) | |
| rate | 0.095 (0.049, 0.167) | 0.168 (0.102, 0.329) | 0.04 (0.014, 0.081) | 0.035 (0.014, 0.071) | 0.035 (0.014, 0.072) | |
| +++- | graduation | 0 | 303 | 33 | 121 | 139 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 15 | 11 | |
| n | 8 (5, 13) | 5 (2, 10) | 8 (4, 12) | 7 (3, 12) | 7 (3, 12) | |
| n_unique | 7 (4, 12) | 4 (1, 9) | 7 (3, 11) | 6 (3, 11) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.29 (0.1, 0.49) | 0.26 (0.08, 0.52) | 0.89 (0.64, 0.99) | 0.89 (0.68, 0.98) | |
| rate | 0.151 (0.09, 0.265) | 0.175 (0.102, 0.368) | 0.162 (0.097, 0.283) | 0.037 (0.015, 0.079) | 0.039 (0.014, 0.073) | |
| ++++ | graduation | 0 | 336 | 190 | 135 | 151 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 8 | 15 | 11 | |
| n | 8 (5, 13) | 5 (1, 10) | 6 (2, 12) | 7 (3, 13) | 7 (3, 12) | |
| n_unique | 8 (4, 13) | 4 (1, 9) | 5 (1, 11) | 7 (3, 11) | 6 (2, 11) | |
| post_p | NA (NA, NA) | 0.22 (0.05, 0.4) | 0.69 (0.45, 0.89) | 0.73 (0.48, 0.93) | 0.7 (0.44, 0.91) | |
| rate | 0.088 (0.047, 0.159) | 0.168 (0.099, 0.365) | 0.039 (0.015, 0.078) | 0.033 (0.013, 0.071) | 0.037 (0.015, 0.07) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 6 | 5 | 1 | 1 |
| time_stop | 4 (4, 5) | 6 (4, 7) | 5 (5, 5) | 4 (4, 4) | |
| n_trt | 26 (25, 28) | 36 (34, 45) | 38 (38, 38) | 29 (29, 29) | |
| n_control | 28 (16, 38) | 39 (26, 43) | 29 (29, 29) | 23 (23, 23) | |
| post_p | 0.88 (0.86, 0.96) | 0.93 (0.88, 0.96) | 0.96 (0.96, 0.96) | 0.98 (0.98, 0.98) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | |
| TP53- & AR- | count | 240 | 1 | ||
| time_stop | 13 (9, 29) | 9 (9, 9) | |||
| n_trt | 31 (25, 83) | 25 (25, 25) | |||
| n_control | 34 (21, 86) | 22 (22, 22) | |||
| post_p | 0.98 (0.91, 1) | 0.92 (0.92, 0.92) | |||
| order | 1 (1, 2) | 1 (1, 1) | |||
| TP53+ | count | 1 | 16 | 1 | 1 |
| time_stop | 9 (9, 9) | 11 (8, 18) | 9 (9, 9) | 10 (10, 10) | |
| n_trt | 29 (29, 29) | 31 (25, 56) | 26 (26, 26) | 26 (26, 26) | |
| n_control | 23 (23, 23) | 36 (22, 64) | 27 (27, 27) | 37 (37, 37) | |
| post_p | 0.86 (0.86, 0.86) | 0.97 (0.89, 1) | 0.97 (0.97, 0.97) | 0.98 (0.98, 0.98) | |
| order | 1 (1, 1) | 1 (1, 2.5) | 1 (1, 1) | 2 (2, 2) | |
| DRD+ | count | 1 | 120 | 132 | |
| time_stop | 13 (13, 13) | 22 (13, 33) | 21 (13, 33) | ||
| n_trt | 26 (26, 26) | 38 (25, 77) | 38 (25, 72) | ||
| n_control | 16 (16, 16) | 42 (24, 77) | 44 (24, 73) | ||
| post_p | 0.92 (0.92, 0.92) | 1 (0.98, 1) | 1 (0.98, 1) | ||
| order | 1 (1, 1) | 2 (1, 3) | 2 (1, 3) | ||
| TEfus+ | count | 163 | 1 | ||
| time_stop | 15 (9, 31) | 11 (11, 11) | |||
| n_trt | 34 (26, 81) | 26 (26, 26) | |||
| n_control | 37 (21, 88) | 27 (27, 27) | |||
| post_p | 0.99 (0.94, 1) | 0.97 (0.97, 0.97) | |||
| order | 1 (1, 2) | 2 (2, 2) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 1 | 1 | ||
| time_stop | 5 (5, 5) | 5 (5, 5) | |||
| n_trt | 37 (37, 37) | 26 (26, 26) | |||
| n_control | 34 (34, 34) | 42 (42, 42) | |||
| post_p | 0.17 (0.17, 0.17) | 0.16 (0.16, 0.16) | |||
| order | 1 (1, 1) | 1 (1, 1) | |||
| TP53- & AR- | count | 1 | 118 | 138 | 119 |
| time_stop | 7 (7, 7) | 14 (9, 27) | 14 (9, 23) | 13 (9, 20) | |
| n_trt | 28 (28, 28) | 37 (26, 70) | 36 (26, 67) | 34 (25, 61) | |
| n_control | 14 (14, 14) | 37 (22, 73) | 36 (21, 67) | 35 (22, 57) | |
| post_p | 0.27 (0.27, 0.27) | 0.07 (0, 0.21) | 0.08 (0, 0.23) | 0.1 (0.01, 0.24) | |
| order | 1 (1, 1) | 1 (1, 3) | 1 (1, 3) | 1 (1, 3) | |
| TP53+ | count | 237 | 1 | 4 | |
| time_stop | 17 (9, 32) | 11 (11, 11) | 11 (10, 16) | ||
| n_trt | 49 (27, 97) | 29 (29, 29) | 32 (29, 45) | ||
| n_control | 49 (25, 99) | 27 (27, 27) | 44 (32, 62) | ||
| post_p | 0.03 (0, 0.14) | 0.08 (0.08, 0.08) | 0.09 (0.05, 0.22) | ||
| order | 2 (1, 3) | 2 (2, 2) | 1.5 (1, 2.7) | ||
| DRD+ | count | 116 | 10 | ||
| time_stop | 19 (13, 26) | 16 (13, 24) | |||
| n_trt | 32 (26, 50) | 33 (29, 49) | |||
| n_control | 37 (22, 55) | 30 (22, 54) | |||
| post_p | 0.05 (0, 0.17) | 0.07 (0.02, 0.2) | |||
| order | 2 (1, 3) | 2 (1, 4) | |||
| TEfus+ | count | 107 | 14 | 13 | |
| time_stop | 16 (11, 33) | 16 (13, 28) | 14 (12, 26) | ||
| n_trt | 39 (26, 64) | 34 (30, 65) | 36 (27, 66) | ||
| n_control | 44 (25, 94) | 42 (32, 74) | 37 (28, 55) | ||
| post_p | 0.02 (0, 0.1) | 0.04 (0, 0.14) | 0.02 (0, 0.2) | ||
| order | 2 (1, 3) | 2 (1, 3) | 3 (1, 3) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| time | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | 4 (4, 5) | ||
| n | 7 (5, 9) | 2 (0, 3) | 4 (2, 6) | 2 (1, 2) | 1 (0, 2) | 2 (0, 2) | 1 (0, 2) | 0 (0, 2) | 2 (1, 2) | 0 (0, 2) | 0 (0, 2) | 2 (0, 2) | 1 (0, 2) | 1 (0, 2) | 2 (0, 2) | 0 (0, 0) | ||
| post_p | 0.63 (0.54, 0.76) | 0.54 (0.52, 0.56) | 0.57 (0.54, 0.81) | 0.56 (0.55, 0.59) | 0.56 (0.52, 0.56) | 0.53 (0.51, 0.55) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.51 (0.5, 0.62) | NA (NA, NA) | 0.57 (0.57, 0.57) | 0.54 (0.53, 0.55) | 0.53 (0.53, 0.53) | 0.53 (0.51, 0.56) | 0.54 (0.53, 0.55) | 0.5 (0.5, 0.5) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0 (0, 0.079) | 0 (0, 0) | 0 (0, 0.14) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.087 (0.017, 0.157) | 0 (0, 0) | 0 (0, 0.234) | 0.157 (0.031, 0.325) | 0 (0, 0) | 0.194 (0, 0.653) | 0 (0, 0) | 0.079 (0, 0.236) | 0 (0, 0) | ||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| time | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | 6 (4, 7) | ||
| n | 9 (8, 14) | 1 (0, 2) | 7 (2, 8) | 3 (1, 7) | 3 (0, 4) | 1 (0, 2) | 0 (0, 2) | 1 (0, 2) | 3 (2, 5) | 1 (0, 4) | 0 (0, 3) | 3 (0, 4) | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) | 2 (0, 3) | ||
| post_p | 0.56 (0.55, 0.72) | 0.54 (0.53, 0.55) | 0.61 (0.53, 0.66) | 0.58 (0.55, 0.61) | 0.54 (0.52, 0.56) | 0.51 (0.5, 0.53) | 0.56 (0.56, 0.56) | 0.53 (0.52, 0.54) | 0.6 (0.51, 0.66) | 0.52 (0.51, 0.59) | 0.54 (0.52, 0.55) | 0.55 (0.52, 0.62) | 0.52 (0.52, 0.55) | 0.52 (0.51, 0.54) | 0.51 (0.51, 0.52) | 0.53 (0.5, 0.59) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.086 (0.051, 0.11) | 0 (0, 0) | 0.031 (0, 0.085) | 0 (0, 0) | 0 (0, 0.041) | 0 (0, 0) | 0.186 (0.186, 0.186) | 0 (0, 0) | 0.078 (0, 0.311) | 0 (0, 0) | 0.085 (0.017, 0.153) | 0 (0, 0.076) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 9 (9, 9) | 0 (0, 0) | 3 (3, 3) | 6 (6, 6) | 4 (4, 4) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 3 (3, 3) | 1 (1, 1) | ||
| post_p | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.5 (0.5, 0.5) | 0.53 (0.53, 0.53) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.58 (0.58, 0.58) | 0.53 (0.53, 0.53) | 0.55 (0.55, 0.55) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.6 (0.6, 0.6) | 0.51 (0.51, 0.51) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.147 (0.147, 0.147) | NA (NA, NA) | 0.113 (0.113, 0.113) | 0.066 (0.066, 0.066) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.396 (0.396, 0.396) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 3 (3, 3) | 0 (0, 0) | 8 (8, 8) | 2 (2, 2) | 1 (1, 1) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 4 (4, 4) | 0 (0, 0) | ||
| post_p | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.65 (0.65, 0.65) | 0.55 (0.55, 0.55) | 0.51 (0.51, 0.51) | 0.51 (0.51, 0.51) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.63 (0.63, 0.63) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | NA (NA, NA) | 0.069 (0.069, 0.069) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0.069 (0.069, 0.069) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | ||
| TP53- & AR- | Hormone_therapies | count | 240 | 240 | 240 | 240 | ||||||||||||
| time | 13 (9, 29) | 13 (9, 29) | 13 (9, 29) | 13 (9, 29) | ||||||||||||||
| n | 21 (15, 52) | 4 (2, 12) | 4 (2, 11) | 4 (1, 13) | ||||||||||||||
| post_p | 0.96 (0.83, 1) | 0.63 (0.53, 0.87) | 0.61 (0.52, 0.81) | 0.56 (0.51, 0.76) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.039 (0.018, 0.062) | 0.024 (0, 0.071) | 0.017 (0, 0.068) | 0 (0, 0.047) | ||||||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | ||||||||||||||
| n | 19 (19, 19) | 3 (3, 3) | 2 (2, 2) | 1 (1, 1) | ||||||||||||||
| post_p | 0.83 (0.83, 0.83) | 0.75 (0.75, 0.75) | 0.52 (0.52, 0.52) | 0.51 (0.51, 0.51) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.055 (0.055, 0.055) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | ||||||||||
| n | 10 (10, 10) | 9 (9, 9) | 2 (2, 2) | 2 (2, 2) | 1 (1, 1) | 2 (2, 2) | 1 (1, 1) | 2 (2, 2) | ||||||||||
| post_p | 0.73 (0.73, 0.73) | 0.74 (0.74, 0.74) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.093 (0.093, 0.093) | 0.042 (0.042, 0.042) | 0 (0, 0) | 0.257 (0.257, 0.257) | 0 (0, 0) | 0.29 (0.29, 0.29) | 1.078 (1.078, 1.078) | 0 (0, 0) | ||||||||||
| Taxel_therapies | count | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | |||||||||
| time | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | 11 (8, 18) | ||||||||||
| n | 11 (7, 20) | 8 (4, 12) | 1 (0, 4) | 2 (0, 6) | 3 (2, 7) | 3 (1, 6) | 2 (0, 4) | 3 (0, 5) | ||||||||||
| post_p | 0.77 (0.7, 0.86) | 0.85 (0.71, 0.96) | 0.53 (0.51, 0.63) | 0.54 (0.52, 0.74) | 0.64 (0.54, 0.8) | 0.62 (0.54, 0.95) | 0.55 (0.51, 0.66) | 0.55 (0.52, 0.6) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.086 (0.057, 0.133) | 0.021 (0, 0.055) | 0 (0, 0.093) | 0 (0, 0.083) | 0.087 (0, 0.145) | 0 (0, 0.04) | 0 (0, 0.126) | 0 (0, 0.037) | ||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | ||||||||||
| n | 7 (7, 7) | 5 (5, 5) | 3 (3, 3) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | ||||||||||
| post_p | 0.81 (0.81, 0.81) | 0.55 (0.55, 0.55) | 0.74 (0.74, 0.74) | 0.53 (0.53, 0.53) | 0.68 (0.68, 0.68) | 0.53 (0.53, 0.53) | 0.52 (0.52, 0.52) | 0.56 (0.56, 0.56) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.074 (0.074, 0.074) | 0.043 (0.043, 0.043) | 0 (0, 0) | 0 (0, 0) | 0.109 (0.109, 0.109) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 8 (8, 8) | 4 (4, 4) | 5 (5, 5) | 1 (1, 1) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | 1 (1, 1) | ||||||||||
| post_p | 0.96 (0.96, 0.96) | 0.61 (0.61, 0.61) | 0.74 (0.74, 0.74) | 0.52 (0.52, 0.52) | 0.5 (0.5, 0.5) | 0.53 (0.53, 0.53) | 0.57 (0.57, 0.57) | 0.54 (0.54, 0.54) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.057 (0.057, 0.057) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.218 (0.218, 0.218) | 0.125 (0.125, 0.125) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| DRD+ | Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||
| n | 4 (4, 4) | 5 (5, 5) | 5 (5, 5) | 3 (3, 3) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 3 (3, 3) | ||||||||||
| post_p | 0.56 (0.56, 0.56) | 0.55 (0.55, 0.55) | 0.69 (0.69, 0.69) | 0.55 (0.55, 0.55) | 0.54 (0.54, 0.54) | 0.52 (0.52, 0.52) | 0.54 (0.54, 0.54) | 0.64 (0.64, 0.64) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.054 (0.054, 0.054) | 0.029 (0.029, 0.029) | 0 (0, 0) | 0.056 (0.056, 0.056) | 0 (0, 0) | 0.101 (0.101, 0.101) | 0 (0, 0) | 0.056 (0.056, 0.056) | ||||||||||
| Carboplatin | count | 120 | 120 | 120 | 120 | 120 | 120 | 120 | 120 | |||||||||
| time | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | 22 (13, 33) | ||||||||||
| n | 6 (3, 16) | 6 (3, 15) | 4 (1, 9) | 4 (1, 10) | 4 (2, 8) | 4 (2, 9) | 5 (2, 10) | 4 (2, 9) | ||||||||||
| post_p | 0.73 (0.54, 0.95) | 0.71 (0.52, 0.85) | 0.73 (0.57, 0.94) | 0.66 (0.53, 0.83) | 0.75 (0.54, 0.93) | 0.67 (0.53, 0.87) | 0.78 (0.57, 0.96) | 0.69 (0.53, 0.84) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.026 (0, 0.052) | 0.026 (0, 0.048) | 0.03 (0, 0.071) | 0.021 (0, 0.057) | 0.028 (0, 0.087) | 0.021 (0, 0.067) | 0.03 (0, 0.07) | 0.022 (0, 0.062) | ||||||||||
| Niraparib | count | 132 | 132 | 132 | 132 | 132 | 132 | 132 | 132 | |||||||||
| time | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | ||||||||||
| n | 8 (3, 14) | 5 (3, 16) | 4 (2, 9) | 4 (1, 9) | 4 (2, 8) | 4 (2, 8) | 4 (2, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.76 (0.55, 0.94) | 0.71 (0.52, 0.82) | 0.73 (0.55, 0.93) | 0.64 (0.52, 0.87) | 0.72 (0.53, 0.91) | 0.65 (0.53, 0.88) | 0.72 (0.58, 0.94) | 0.64 (0.52, 0.85) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.026 (0, 0.056) | 0.022 (0, 0.04) | 0.029 (0, 0.071) | 0.022 (0, 0.064) | 0.029 (0, 0.08) | 0.019 (0, 0.056) | 0.029 (0, 0.074) | 0.021 (0, 0.063) | ||||||||||
| TEfus+ | Taxel_therapies | count | 163 | 163 | 163 | 163 | 163 | 163 | 163 | 163 | ||||||||
| time | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | 15 (9, 31) | ||||||||||
| n | 5 (2, 12) | 11 (6, 23) | 4 (2, 13) | 3 (1, 7) | 4 (1, 10) | 4 (2, 10) | 3 (1, 7) | 3 (1, 9) | ||||||||||
| post_p | 0.69 (0.54, 0.9) | 0.92 (0.75, 1) | 0.58 (0.51, 0.78) | 0.59 (0.52, 0.81) | 0.74 (0.56, 0.96) | 0.72 (0.54, 0.97) | 0.59 (0.52, 0.82) | 0.58 (0.52, 0.84) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.03 (0, 0.068) | 0.034 (0, 0.059) | 0.012 (0, 0.045) | 0 (0, 0.056) | 0.023 (0, 0.073) | 0.037 (0, 0.087) | 0.01 (0, 0.067) | 0.016 (0, 0.074) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||
| n | 2 (2, 2) | 5 (5, 5) | 3 (3, 3) | 4 (4, 4) | 3 (3, 3) | 3 (3, 3) | 4 (4, 4) | 2 (2, 2) | ||||||||||
| post_p | 0.52 (0.52, 0.52) | 0.69 (0.69, 0.69) | 0.54 (0.54, 0.54) | 0.56 (0.56, 0.56) | 0.69 (0.69, 0.69) | 0.59 (0.59, 0.59) | 0.61 (0.61, 0.61) | 0.62 (0.62, 0.62) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.041 (0.041, 0.041) | 0 (0, 0) | 0.045 (0.045, 0.045) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 10 (10, 10) | 1 (1, 1) | 5 (5, 5) | 8 (8, 8) | 5 (5, 5) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.38 (0.38, 0.38) | 0.5 (0.5, 0.5) | 0.45 (0.45, 0.45) | 0.41 (0.41, 0.41) | 0.49 (0.49, 0.49) | 0.44 (0.44, 0.44) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.47 (0.47, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.181 (0.181, 0.181) | 0 (0, 0) | 0.203 (0.203, 0.203) | 0.217 (0.217, 0.217) | 0.071 (0.071, 0.071) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.455 (0.455, 0.455) | NA (NA, NA) | 0 (0, 0) | 0.32 (0.32, 0.32) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 6 (6, 6) | 0 (0, 0) | 6 (6, 6) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 2 (2, 2) | 1 (1, 1) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | ||
| post_p | 0.29 (0.29, 0.29) | NA (NA, NA) | 0.49 (0.49, 0.49) | NA (NA, NA) | 0.49 (0.49, 0.49) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.39 (0.39, 0.39) | 0.43 (0.43, 0.43) | 0.46 (0.46, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.281 (0.281, 0.281) | NA (NA, NA) | 0.153 (0.153, 0.153) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0.695 (0.695, 0.695) | 0.452 (0.452, 0.452) | 1.037 (1.037, 1.037) | 0.108 (0.108, 0.108) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||
| TP53- & AR- | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||||||||||
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||||||||||||||
| n | 20 (20, 20) | 4 (4, 4) | 0 (0, 0) | 4 (4, 4) | ||||||||||||||
| post_p | 0.37 (0.37, 0.37) | 0.49 (0.49, 0.49) | NA (NA, NA) | 0.44 (0.44, 0.44) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.14 (0.14, 0.14) | 0.109 (0.109, 0.109) | NA (NA, NA) | 0.067 (0.067, 0.067) | ||||||||||||||
| Taxel_therapies | count | 118 | 118 | 118 | 118 | |||||||||||||
| time | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | ||||||||||||||
| n | 23 (16, 45) | 4 (1, 8) | 5 (2, 10) | 4 (2, 8) | ||||||||||||||
| post_p | 0.12 (0.01, 0.38) | 0.47 (0.37, 0.5) | 0.32 (0.08, 0.46) | 0.46 (0.34, 0.49) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.157 (0.121, 0.219) | 0.081 (0.04, 0.16) | 0.166 (0.084, 0.31) | 0.058 (0.026, 0.141) | ||||||||||||||
| Carboplatin | count | 138 | 138 | 138 | 138 | |||||||||||||
| time | 14 (9, 23) | 14 (9, 23) | 14 (9, 23) | 14 (9, 23) | ||||||||||||||
| n | 23 (16, 44) | 5 (2, 10) | 4 (2, 8) | 5 (2, 10) | ||||||||||||||
| post_p | 0.14 (0, 0.31) | 0.33 (0.09, 0.46) | 0.46 (0.36, 0.49) | 0.44 (0.35, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.155 (0.119, 0.23) | 0.169 (0.081, 0.419) | 0.085 (0.041, 0.216) | 0.053 (0.025, 0.129) | ||||||||||||||
| Niraparib | count | 119 | 119 | 119 | 119 | |||||||||||||
| time | 13 (9, 20) | 13 (9, 20) | 13 (9, 20) | 13 (9, 20) | ||||||||||||||
| n | 22 (15, 37) | 5 (2, 9) | 4 (1, 8) | 4 (2, 10) | ||||||||||||||
| post_p | 0.2 (0.02, 0.39) | 0.35 (0.17, 0.46) | 0.45 (0.39, 0.49) | 0.45 (0.37, 0.49) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.153 (0.116, 0.217) | 0.16 (0.085, 0.321) | 0.085 (0.047, 0.234) | 0.062 (0.031, 0.136) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 237 | 237 | 237 | 237 | 237 | 237 | 237 | 237 | ||||||||
| time | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | 17 (9, 32) | ||||||||||
| n | 16 (8, 33) | 11 (6, 23) | 3 (1, 7) | 3 (1, 7) | 4 (1, 9) | 4 (1, 10) | 3 (1, 7) | 3 (1, 8) | ||||||||||
| post_p | 0.34 (0.13, 0.48) | 0.25 (0.04, 0.44) | 0.4 (0.22, 0.48) | 0.36 (0.15, 0.47) | 0.39 (0.18, 0.49) | 0.38 (0.13, 0.47) | 0.4 (0.18, 0.47) | 0.34 (0.09, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.18 (0.139, 0.256) | 0.162 (0.115, 0.259) | 0.177 (0.082, 0.426) | 0.162 (0.077, 0.437) | 0.213 (0.136, 0.525) | 0.19 (0.114, 0.486) | 0.189 (0.103, 0.544) | 0.181 (0.077, 0.448) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||
| n | 10 (10, 10) | 9 (9, 9) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 3 (3, 3) | 3 (3, 3) | ||||||||||
| post_p | 0.44 (0.44, 0.44) | 0.4 (0.4, 0.4) | 0.28 (0.28, 0.28) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.17 (0.17, 0.17) | 0.5 (0.5, 0.5) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.173 (0.173, 0.173) | 0.142 (0.142, 0.142) | 0.399 (0.399, 0.399) | NA (NA, NA) | NA (NA, NA) | 0.08 (0.08, 0.08) | 0.168 (0.168, 0.168) | 0.134 (0.134, 0.134) | ||||||||||
| Niraparib | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | 11 (10, 16) | ||||||||||
| n | 13 (12, 14) | 8 (4, 10) | 2 (1, 4) | 0 (0, 1) | 4 (3, 6) | 4 (2, 6) | 1 (0, 3) | 2 (1, 4) | ||||||||||
| post_p | 0.33 (0.29, 0.39) | 0.41 (0.13, 0.48) | 0.45 (0.34, 0.49) | 0.45 (0.42, 0.49) | 0.44 (0.33, 0.48) | 0.32 (0.14, 0.36) | 0.48 (0.48, 0.49) | 0.45 (0.42, 0.45) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.207 (0.177, 0.255) | 0.102 (0.081, 0.307) | 0.129 (0.026, 0.187) | 0.674 (0.135, 1.212) | 0.206 (0.152, 0.244) | 0.194 (0.132, 0.312) | 0.064 (0.06, 0.069) | 0.157 (0.066, 0.53) | ||||||||||
| DRD+ | Hormone_therapies | count | 116 | 116 | 116 | 116 | 116 | 116 | 116 | 116 | ||||||||
| time | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | 19 (13, 26) | ||||||||||
| n | 5 (2, 12) | 5 (2, 11) | 4 (2, 6) | 3 (1, 7) | 4 (2, 7) | 4 (1, 7) | 4 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.45 (0.3, 0.49) | 0.43 (0.28, 0.49) | 0.36 (0.2, 0.48) | 0.34 (0.16, 0.46) | 0.36 (0.16, 0.47) | 0.34 (0.14, 0.45) | 0.37 (0.16, 0.47) | 0.35 (0.17, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.072 (0.048, 0.158) | 0.053 (0.032, 0.13) | 0.183 (0.083, 0.426) | 0.179 (0.088, 0.391) | 0.178 (0.092, 0.471) | 0.169 (0.1, 0.417) | 0.186 (0.102, 0.577) | 0.165 (0.075, 0.57) | ||||||||||
| Taxel_therapies | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |||||||||
| time | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | 16 (13, 24) | ||||||||||
| n | 8 (4, 10) | 7 (2, 10) | 4 (2, 6) | 3 (1, 5) | 5 (3, 7) | 4 (2, 9) | 4 (0, 8) | 4 (2, 5) | ||||||||||
| post_p | 0.22 (0.12, 0.47) | 0.4 (0.29, 0.49) | 0.4 (0.18, 0.47) | 0.44 (0.37, 0.48) | 0.34 (0.28, 0.48) | 0.46 (0.41, 0.49) | 0.33 (0.21, 0.4) | 0.43 (0.3, 0.5) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.184 (0.093, 0.275) | 0.082 (0.049, 0.162) | 0.171 (0.153, 0.416) | 0.067 (0.045, 0.184) | 0.204 (0.095, 0.356) | 0.08 (0.06, 0.193) | 0.225 (0.164, 0.309) | 0.094 (0.015, 0.142) | ||||||||||
| TEfus+ | Hormone_therapies | count | 107 | 107 | 107 | 107 | 107 | 107 | 107 | 107 | ||||||||
| time | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | 16 (11, 33) | ||||||||||
| n | 5 (2, 10) | 10 (6, 18) | 5 (2, 11) | 3 (1, 7) | 5 (2, 9) | 4 (1, 8) | 3 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.44 (0.31, 0.49) | 0.21 (0.05, 0.44) | 0.44 (0.31, 0.49) | 0.37 (0.15, 0.45) | 0.36 (0.15, 0.45) | 0.38 (0.15, 0.48) | 0.32 (0.12, 0.45) | 0.35 (0.09, 0.45) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.091 (0.053, 0.223) | 0.173 (0.118, 0.268) | 0.054 (0.03, 0.131) | 0.183 (0.09, 0.46) | 0.189 (0.109, 0.39) | 0.196 (0.101, 0.768) | 0.177 (0.092, 0.421) | 0.188 (0.088, 0.423) | ||||||||||
| Carboplatin | count | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | |||||||||
| time | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | 16 (13, 28) | ||||||||||
| n | 5 (2, 11) | 9 (5, 12) | 5 (3, 9) | 4 (0, 5) | 4 (2, 8) | 4 (2, 7) | 3 (2, 7) | 3 (1, 6) | ||||||||||
| post_p | 0.24 (0.08, 0.41) | 0.24 (0.15, 0.39) | 0.46 (0.36, 0.48) | 0.44 (0.27, 0.49) | 0.39 (0.2, 0.48) | 0.29 (0.09, 0.44) | 0.45 (0.33, 0.47) | 0.44 (0.39, 0.49) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.205 (0.111, 0.358) | 0.156 (0.097, 0.182) | 0.044 (0.029, 0.113) | 0.071 (0.032, 0.134) | 0.137 (0.084, 0.376) | 0.175 (0.117, 0.403) | 0.104 (0.051, 0.165) | 0.138 (0.04, 0.384) | ||||||||||
| Niraparib | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | |||||||||
| time | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | 14 (12, 26) | ||||||||||
| n | 3 (3, 5) | 11 (8, 24) | 4 (2, 9) | 3 (0, 4) | 4 (2, 9) | 5 (2, 9) | 2 (0, 11) | 3 (0, 5) | ||||||||||
| post_p | 0.3 (0.13, 0.45) | 0.12 (0.01, 0.32) | 0.43 (0.27, 0.49) | 0.44 (0.4, 0.48) | 0.41 (0.24, 0.48) | 0.39 (0.18, 0.46) | 0.42 (0.36, 0.49) | 0.42 (0.34, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.147 (0.094, 0.387) | 0.164 (0.132, 0.255) | 0.062 (0.044, 0.132) | 0.065 (0.021, 0.256) | 0.21 (0.144, 0.344) | 0.206 (0.113, 0.261) | 0.131 (0.079, 0.401) | 0.118 (0.042, 0.653) |