Setting description

Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
DRD+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 25, median = 18 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 2.85, hr = 0.33 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 6 5 1 1
TP53- & AR- 240 0 0 1
TP53+ 1 16 1 1
DRD+ 0 1 120 132
TEfus+ 0 163 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.012 0.010 0.002 0.002
TP53- & AR- 0.480 0.000 0.000 0.002
TP53+ 0.002 0.032 0.002 0.002
DRD+ 0.000 0.002 0.240 0.264
TEfus+ 0.000 0.326 0.000 0.002
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 1 1
TP53- & AR- 1 118 138 119
TP53+ 237 1 0 4
DRD+ 116 10 0 0
TEfus+ 107 0 14 13
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.002 0.002
TP53- & AR- 0.002 0.236 0.276 0.238
TP53+ 0.474 0.002 0.000 0.008
DRD+ 0.232 0.020 0.000 0.000
TEfus+ 0.214 0.000 0.028 0.026
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 3 17 15 23
TP53+ 0 8 17 11
DRD+ 0 0 0 0
TEfus+ 0 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.006 0.034 0.030 0.046
TP53+ 0.000 0.016 0.034 0.022
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.056.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.034             0.004             0.006

The overall power was 0.798.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.480             0.326             0.240             0.264

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 6 5 1 1
futility 0 0 0 1 1
max_n 0 0 0 0 0
n 276 (245, 318) 181 (121, 251) 235 (173, 292) 246 (183, 291) 247 (185, 292)
n_unique 252 (223, 291) 164 (109, 231) 215 (156, 264) 224 (166, 268) 225 (167, 266)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (4, 5) 6 (4, 7) 5 (5, 5) 4 (4, 5)
post_p NA (NA, NA) 0.57 (0.04, 0.98) 0.58 (0.05, 0.96) 0.29 (0.02, 0.78) 0.22 (0.02, 0.7)
rate 0.094 (0.085, 0.104) 0.09 (0.074, 0.112) 0.091 (0.079, 0.109) 0.1 (0.089, 0.113) 0.101 (0.09, 0.115)
TP53- & AR- graduation 0 240 0 0 1
futility 0 1 118 138 119
max_n 0 3 17 15 23
n 116 (95, 145) 77 (26, 116) 98 (32, 130) 97 (31, 132) 99 (29, 135)
n_unique 108 (87, 135) 72 (24, 105) 89 (29, 118) 89 (29, 122) 91 (27, 123)
time_trial 36 (36, 36) 36 (10, 36) 36 (13, 36) 36 (12, 36) 36 (12, 36)
time_stop NA (NA, NA) 13 (9, 29) 14 (9, 27) 14 (9, 23) 13 (9, 20)
post_p NA (NA, NA) 1 (0.93, 1) 0.02 (0, 0.18) 0.03 (0, 0.26) 0.03 (0, 0.24)
rate 0.073 (0.063, 0.086) 0.043 (0.034, 0.052) 0.109 (0.091, 0.134) 0.105 (0.088, 0.134) 0.105 (0.089, 0.132)
TP53+ graduation 0 1 16 1 1
futility 0 237 1 0 4
max_n 0 0 8 17 11
n 119 (103, 143) 87 (29, 119) 108 (76, 133) 115 (94, 138) 114 (94, 136)
n_unique 108 (94, 131) 78 (27, 107) 98 (68, 120) 104 (85, 125) 103 (84, 123)
time_trial 36 (36, 36) 36 (11, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 17 (9, 32) 11 (8, 18) 9 (9, 9) 10 (10, 16)
post_p NA (NA, NA) 0.02 (0, 0.16) 0.97 (0.61, 1) 0.72 (0.22, 0.97) 0.66 (0.21, 0.96)
rate 0.113 (0.097, 0.131) 0.159 (0.138, 0.197) 0.084 (0.068, 0.103) 0.103 (0.086, 0.122) 0.105 (0.089, 0.123)
DRD+ graduation 0 0 1 120 132
futility 0 116 10 0 0
max_n 0 0 0 0 0
n 80 (65, 99) 49 (28, 77) 67 (43, 91) 69 (33, 91) 68 (32, 89)
n_unique 74 (59, 92) 44 (25, 68) 59 (38, 81) 62 (29, 81) 61 (30, 81)
time_trial 36 (36, 36) 36 (18, 36) 36 (36, 36) 36 (19, 36) 36 (18, 36)
time_stop NA (NA, NA) 19 (13, 26) 16 (13, 23) 22 (13, 33) 21 (13, 33)
post_p NA (NA, NA) 0.21 (0.02, 0.71) 0.57 (0.12, 0.94) 1 (0.99, 1) 1 (0.99, 1)
rate 0.091 (0.074, 0.111) 0.098 (0.073, 0.129) 0.078 (0.062, 0.1) 0.036 (0.027, 0.045) 0.037 (0.028, 0.045)
TEfus+ graduation 0 0 163 0 1
futility 0 107 0 14 13
max_n 0 0 0 0 0
n 105 (87, 128) 69 (34, 99) 86 (27, 112) 94 (72, 117) 94 (69, 118)
n_unique 96 (79, 118) 61 (30, 89) 77 (25, 101) 85 (65, 105) 85 (62, 107)
time_trial 36 (36, 36) 36 (16, 36) 36 (12, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 16 (11, 33) 15 (9, 31) 16 (13, 28) 14 (11, 25)
post_p NA (NA, NA) 0.03 (0, 0.3) 1 (0.98, 1) 0.18 (0.01, 0.62) 0.14 (0.01, 0.58)
rate 0.074 (0.062, 0.088) 0.108 (0.083, 0.136) 0.038 (0.03, 0.046) 0.086 (0.072, 0.107) 0.089 (0.074, 0.109)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 247 123 140 122
futility 0 0 0 0 0
max_n 0 3 17 15 23
n 70 (55, 89) 50 (16, 73) 62 (20, 83) 60 (20, 82) 60 (20, 84)
n_unique 64 (50, 85) 47 (15, 68) 58 (19, 78) 56 (19, 77) 56 (19, 78)
post_p NA (NA, NA) 1 (0.95, 1) 0 (0, 0.06) 0 (0, 0.06) 0 (0, 0.07)
rate 0.083 (0.069, 0.102) 0.043 (0.033, 0.057) 0.159 (0.134, 0.194) 0.161 (0.133, 0.198) 0.158 (0.132, 0.191)
—+ graduation 0 318 253 148 130
futility 0 0 0 0 0
max_n 0 3 17 15 23
n 15 (9, 22) 7 (2, 17) 10 (2, 18) 12 (4, 19) 14 (4, 20)
n_unique 14 (9, 21) 6 (2, 16) 9 (2, 16) 11 (3, 17) 12 (4, 19)
post_p NA (NA, NA) 0.76 (0.38, 0.95) 0.81 (0.46, 0.98) 0.06 (0, 0.24) 0.05 (0, 0.22)
rate 0.052 (0.031, 0.082) 0.042 (0.02, 0.089) 0.038 (0.02, 0.075) 0.161 (0.111, 0.25) 0.164 (0.112, 0.242)
–+- graduation 0 244 22 3 7
futility 0 0 0 0 0
max_n 0 0 8 17 11
n 38 (29, 48) 29 (10, 42) 36 (29, 46) 37 (29, 46) 37 (29, 47)
n_unique 35 (26, 43) 26 (9, 39) 34 (26, 42) 34 (26, 43) 34 (27, 43)
post_p NA (NA, NA) 0.42 (0.1, 0.8) 0.4 (0.08, 0.81) 0.43 (0.11, 0.82) 0.38 (0.07, 0.76)
rate 0.147 (0.118, 0.184) 0.164 (0.127, 0.22) 0.159 (0.126, 0.201) 0.157 (0.126, 0.199) 0.164 (0.13, 0.205)
–++ graduation 0 294 181 17 20
futility 0 0 0 0 0
max_n 0 0 8 17 11
n 27 (20, 36) 17 (6, 28) 22 (8, 31) 27 (18, 35) 26 (18, 35)
n_unique 25 (18, 33) 16 (6, 26) 19 (7, 28) 24 (16, 32) 24 (16, 32)
post_p NA (NA, NA) 0.1 (0.01, 0.35) 0.99 (0.92, 1) 0.06 (0, 0.28) 0.05 (0, 0.26)
rate 0.087 (0.062, 0.119) 0.163 (0.117, 0.234) 0.037 (0.023, 0.056) 0.158 (0.122, 0.204) 0.161 (0.123, 0.216)
-+– graduation 0 333 131 245 235
futility 0 0 0 0 0
max_n 0 3 17 14 21
n 15 (10, 22) 8 (2, 17) 13 (4, 20) 10 (3, 19) 11 (3, 19)
n_unique 14 (9, 20) 7 (2, 15) 12 (4, 18) 9 (2, 17) 10 (2, 17)
post_p NA (NA, NA) 0.76 (0.4, 0.96) 0.06 (0, 0.3) 0.83 (0.46, 0.98) 0.83 (0.48, 0.98)
rate 0.083 (0.053, 0.132) 0.043 (0.019, 0.08) 0.161 (0.109, 0.243) 0.036 (0.019, 0.078) 0.038 (0.02, 0.076)
-+-+ graduation 0 373 259 253 242
futility 0 0 0 0 0
max_n 0 3 17 14 21
n 16 (10, 22) 6 (2, 17) 10 (2, 19) 11 (3, 20) 12 (3, 20)
n_unique 14 (8, 21) 5 (2, 16) 9 (2, 17) 10 (3, 18) 11 (3, 18)
post_p NA (NA, NA) 0.52 (0.25, 0.78) 0.57 (0.3, 0.84) 0.59 (0.29, 0.86) 0.6 (0.32, 0.87)
rate 0.054 (0.032, 0.086) 0.043 (0.02, 0.077) 0.04 (0.019, 0.074) 0.037 (0.019, 0.071) 0.038 (0.02, 0.069)
-++- graduation 0 303 33 121 139
futility 0 0 0 0 0
max_n 0 0 8 15 11
n 8 (5, 13) 5 (2, 10) 8 (4, 12) 7 (3, 12) 7 (3, 11)
n_unique 7 (4, 12) 4 (1, 9) 7 (3, 11) 6 (2, 11) 6 (2, 10)
post_p NA (NA, NA) 0.29 (0.12, 0.55) 0.26 (0.06, 0.54) 0.89 (0.67, 0.98) 0.9 (0.65, 0.98)
rate 0.15 (0.092, 0.263) 0.171 (0.089, 0.356) 0.16 (0.096, 0.278) 0.035 (0.012, 0.07) 0.035 (0.012, 0.074)
-+++ graduation 0 336 190 135 151
futility 0 0 0 0 0
max_n 0 0 8 15 11
n 8 (4, 13) 5 (1, 9) 6 (2, 12) 8 (3, 12) 7 (2, 12)
n_unique 7 (4, 12) 4 (1, 8) 5 (1, 11) 7 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.21 (0.05, 0.39) 0.7 (0.43, 0.9) 0.69 (0.43, 0.92) 0.72 (0.45, 0.92)
rate 0.091 (0.045, 0.179) 0.169 (0.095, 0.391) 0.037 (0.014, 0.08) 0.036 (0.016, 0.073) 0.034 (0.013, 0.072)
+— graduation 0 6 5 2 2
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 12 (7, 17) 12 (8, 17) 12 (8, 17) 12 (7, 17)
n_unique 10 (7, 15) 11 (6, 15) 11 (7, 15) 10 (6, 15) 11 (6, 16)
post_p NA (NA, NA) 0.47 (0.16, 0.8) 0.46 (0.14, 0.82) 0.45 (0.16, 0.82) 0.47 (0.17, 0.79)
rate 0.149 (0.095, 0.233) 0.159 (0.11, 0.244) 0.162 (0.106, 0.255) 0.163 (0.108, 0.245) 0.16 (0.108, 0.236)
+–+ graduation 0 113 168 16 16
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 10 (6, 15) 9 (4, 14) 8 (3, 14) 10 (6, 15) 10 (6, 15)
n_unique 9 (5, 14) 8 (3, 13) 8 (3, 13) 9 (5, 13) 9 (5, 14)
post_p NA (NA, NA) 0.23 (0.06, 0.51) 0.94 (0.73, 0.99) 0.23 (0.06, 0.51) 0.21 (0.05, 0.52)
rate 0.088 (0.048, 0.156) 0.169 (0.107, 0.274) 0.039 (0.016, 0.067) 0.162 (0.107, 0.256) 0.167 (0.105, 0.261)
+-+- graduation 0 244 22 3 7
futility 0 0 0 0 0
max_n 0 0 8 17 11
n 10 (6, 14) 7 (2, 13) 10 (6, 15) 10 (6, 14) 10 (6, 15)
n_unique 9 (5, 13) 6 (2, 12) 9 (5, 14) 9 (5, 13) 9 (5, 14)
post_p NA (NA, NA) 0.44 (0.18, 0.78) 0.47 (0.13, 0.8) 0.49 (0.18, 0.81) 0.49 (0.19, 0.8)
rate 0.153 (0.093, 0.238) 0.175 (0.108, 0.368) 0.166 (0.105, 0.27) 0.159 (0.102, 0.249) 0.16 (0.103, 0.244)
+-++ graduation 0 294 181 17 20
futility 0 0 0 0 0
max_n 0 0 8 17 11
n 11 (7, 17) 7 (2, 13) 9 (3, 14) 10 (6, 16) 10 (6, 16)
n_unique 10 (6, 15) 6 (2, 12) 8 (2, 13) 9 (5, 15) 9 (5, 15)
post_p NA (NA, NA) 0.26 (0.07, 0.53) 0.93 (0.67, 0.99) 0.2 (0.04, 0.5) 0.2 (0.04, 0.46)
rate 0.087 (0.049, 0.148) 0.168 (0.102, 0.36) 0.04 (0.017, 0.08) 0.158 (0.108, 0.264) 0.164 (0.11, 0.26)
++– graduation 0 122 16 122 134
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (4, 12) 6 (2, 11) 7 (4, 12) 7 (3, 12) 7 (3, 11)
n_unique 7 (4, 11) 6 (2, 10) 7 (3, 11) 6 (3, 10) 6 (2, 10)
post_p NA (NA, NA) 0.28 (0.09, 0.51) 0.25 (0.08, 0.52) 0.89 (0.65, 0.99) 0.89 (0.64, 0.98)
rate 0.153 (0.091, 0.258) 0.165 (0.104, 0.307) 0.162 (0.094, 0.296) 0.036 (0.013, 0.07) 0.036 (0.013, 0.074)
++-+ graduation 0 191 177 136 147
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (4, 13) 6 (2, 11) 6 (2, 11) 7 (3, 12) 7 (3, 11)
n_unique 7 (4, 12) 6 (2, 10) 6 (2, 10) 6 (2, 11) 6 (2, 10)
post_p NA (NA, NA) 0.17 (0.04, 0.37) 0.7 (0.43, 0.9) 0.74 (0.47, 0.92) 0.74 (0.48, 0.91)
rate 0.095 (0.049, 0.167) 0.168 (0.102, 0.329) 0.04 (0.014, 0.081) 0.035 (0.014, 0.071) 0.035 (0.014, 0.072)
+++- graduation 0 303 33 121 139
futility 0 0 0 0 0
max_n 0 0 8 15 11
n 8 (5, 13) 5 (2, 10) 8 (4, 12) 7 (3, 12) 7 (3, 12)
n_unique 7 (4, 12) 4 (1, 9) 7 (3, 11) 6 (3, 11) 6 (2, 11)
post_p NA (NA, NA) 0.29 (0.1, 0.49) 0.26 (0.08, 0.52) 0.89 (0.64, 0.99) 0.89 (0.68, 0.98)
rate 0.151 (0.09, 0.265) 0.175 (0.102, 0.368) 0.162 (0.097, 0.283) 0.037 (0.015, 0.079) 0.039 (0.014, 0.073)
++++ graduation 0 336 190 135 151
futility 0 0 0 0 0
max_n 0 0 8 15 11
n 8 (5, 13) 5 (1, 10) 6 (2, 12) 7 (3, 13) 7 (3, 12)
n_unique 8 (4, 13) 4 (1, 9) 5 (1, 11) 7 (3, 11) 6 (2, 11)
post_p NA (NA, NA) 0.22 (0.05, 0.4) 0.69 (0.45, 0.89) 0.73 (0.48, 0.93) 0.7 (0.44, 0.91)
rate 0.088 (0.047, 0.159) 0.168 (0.099, 0.365) 0.039 (0.015, 0.078) 0.033 (0.013, 0.071) 0.037 (0.015, 0.07)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 6 5 1 1
time_stop 4 (4, 5) 6 (4, 7) 5 (5, 5) 4 (4, 4)
n_trt 26 (25, 28) 36 (34, 45) 38 (38, 38) 29 (29, 29)
n_control 28 (16, 38) 39 (26, 43) 29 (29, 29) 23 (23, 23)
post_p 0.88 (0.86, 0.96) 0.93 (0.88, 0.96) 0.96 (0.96, 0.96) 0.98 (0.98, 0.98)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 240 1
time_stop 13 (9, 29) 9 (9, 9)
n_trt 31 (25, 83) 25 (25, 25)
n_control 34 (21, 86) 22 (22, 22)
post_p 0.98 (0.91, 1) 0.92 (0.92, 0.92)
order 1 (1, 2) 1 (1, 1)
TP53+ count 1 16 1 1
time_stop 9 (9, 9) 11 (8, 18) 9 (9, 9) 10 (10, 10)
n_trt 29 (29, 29) 31 (25, 56) 26 (26, 26) 26 (26, 26)
n_control 23 (23, 23) 36 (22, 64) 27 (27, 27) 37 (37, 37)
post_p 0.86 (0.86, 0.86) 0.97 (0.89, 1) 0.97 (0.97, 0.97) 0.98 (0.98, 0.98)
order 1 (1, 1) 1 (1, 2.5) 1 (1, 1) 2 (2, 2)
DRD+ count 1 120 132
time_stop 13 (13, 13) 22 (13, 33) 21 (13, 33)
n_trt 26 (26, 26) 38 (25, 77) 38 (25, 72)
n_control 16 (16, 16) 42 (24, 77) 44 (24, 73)
post_p 0.92 (0.92, 0.92) 1 (0.98, 1) 1 (0.98, 1)
order 1 (1, 1) 2 (1, 3) 2 (1, 3)
TEfus+ count 163 1
time_stop 15 (9, 31) 11 (11, 11)
n_trt 34 (26, 81) 26 (26, 26)
n_control 37 (21, 88) 27 (27, 27)
post_p 0.99 (0.94, 1) 0.97 (0.97, 0.97)
order 1 (1, 2) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1 1
time_stop 5 (5, 5) 5 (5, 5)
n_trt 37 (37, 37) 26 (26, 26)
n_control 34 (34, 34) 42 (42, 42)
post_p 0.17 (0.17, 0.17) 0.16 (0.16, 0.16)
order 1 (1, 1) 1 (1, 1)
TP53- & AR- count 1 118 138 119
time_stop 7 (7, 7) 14 (9, 27) 14 (9, 23) 13 (9, 20)
n_trt 28 (28, 28) 37 (26, 70) 36 (26, 67) 34 (25, 61)
n_control 14 (14, 14) 37 (22, 73) 36 (21, 67) 35 (22, 57)
post_p 0.27 (0.27, 0.27) 0.07 (0, 0.21) 0.08 (0, 0.23) 0.1 (0.01, 0.24)
order 1 (1, 1) 1 (1, 3) 1 (1, 3) 1 (1, 3)
TP53+ count 237 1 4
time_stop 17 (9, 32) 11 (11, 11) 11 (10, 16)
n_trt 49 (27, 97) 29 (29, 29) 32 (29, 45)
n_control 49 (25, 99) 27 (27, 27) 44 (32, 62)
post_p 0.03 (0, 0.14) 0.08 (0.08, 0.08) 0.09 (0.05, 0.22)
order 2 (1, 3) 2 (2, 2) 1.5 (1, 2.7)
DRD+ count 116 10
time_stop 19 (13, 26) 16 (13, 24)
n_trt 32 (26, 50) 33 (29, 49)
n_control 37 (22, 55) 30 (22, 54)
post_p 0.05 (0, 0.17) 0.07 (0.02, 0.2)
order 2 (1, 3) 2 (1, 4)
TEfus+ count 107 14 13
time_stop 16 (11, 33) 16 (13, 28) 14 (12, 26)
n_trt 39 (26, 64) 34 (30, 65) 36 (27, 66)
n_control 44 (25, 94) 42 (32, 74) 37 (28, 55)
post_p 0.02 (0, 0.1) 0.04 (0, 0.14) 0.02 (0, 0.2)
order 2 (1, 3) 2 (1, 3) 3 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 7 (5, 9) 2 (0, 3) 4 (2, 6) 2 (1, 2) 1 (0, 2) 2 (0, 2) 1 (0, 2) 0 (0, 2) 2 (1, 2) 0 (0, 2) 0 (0, 2) 2 (0, 2) 1 (0, 2) 1 (0, 2) 2 (0, 2) 0 (0, 0)
post_p 0.63 (0.54, 0.76) 0.54 (0.52, 0.56) 0.57 (0.54, 0.81) 0.56 (0.55, 0.59) 0.56 (0.52, 0.56) 0.53 (0.51, 0.55) 0.52 (0.52, 0.52) NA (NA, NA) 0.51 (0.5, 0.62) NA (NA, NA) 0.57 (0.57, 0.57) 0.54 (0.53, 0.55) 0.53 (0.53, 0.53) 0.53 (0.51, 0.56) 0.54 (0.53, 0.55) 0.5 (0.5, 0.5)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0.079) 0 (0, 0) 0 (0, 0.14) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.087 (0.017, 0.157) 0 (0, 0) 0 (0, 0.234) 0.157 (0.031, 0.325) 0 (0, 0) 0.194 (0, 0.653) 0 (0, 0) 0.079 (0, 0.236) 0 (0, 0)
Taxel_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7) 6 (4, 7)
n 9 (8, 14) 1 (0, 2) 7 (2, 8) 3 (1, 7) 3 (0, 4) 1 (0, 2) 0 (0, 2) 1 (0, 2) 3 (2, 5) 1 (0, 4) 0 (0, 3) 3 (0, 4) 1 (0, 2) 0 (0, 2) 0 (0, 2) 2 (0, 3)
post_p 0.56 (0.55, 0.72) 0.54 (0.53, 0.55) 0.61 (0.53, 0.66) 0.58 (0.55, 0.61) 0.54 (0.52, 0.56) 0.51 (0.5, 0.53) 0.56 (0.56, 0.56) 0.53 (0.52, 0.54) 0.6 (0.51, 0.66) 0.52 (0.51, 0.59) 0.54 (0.52, 0.55) 0.55 (0.52, 0.62) 0.52 (0.52, 0.55) 0.52 (0.51, 0.54) 0.51 (0.51, 0.52) 0.53 (0.5, 0.59)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.051, 0.11) 0 (0, 0) 0.031 (0, 0.085) 0 (0, 0) 0 (0, 0.041) 0 (0, 0) 0.186 (0.186, 0.186) 0 (0, 0) 0.078 (0, 0.311) 0 (0, 0) 0.085 (0.017, 0.153) 0 (0, 0.076) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 9 (9, 9) 0 (0, 0) 3 (3, 3) 6 (6, 6) 4 (4, 4) 2 (2, 2) 0 (0, 0) 1 (1, 1) 1 (1, 1) 1 (1, 1) 3 (3, 3) 1 (1, 1) 0 (0, 0) 3 (3, 3) 3 (3, 3) 1 (1, 1)
post_p 0.56 (0.56, 0.56) NA (NA, NA) 0.55 (0.55, 0.55) 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) 0.55 (0.55, 0.55) NA (NA, NA) 0.51 (0.51, 0.51) 0.58 (0.58, 0.58) 0.53 (0.53, 0.53) 0.55 (0.55, 0.55) 0.57 (0.57, 0.57) NA (NA, NA) 0.55 (0.55, 0.55) 0.6 (0.6, 0.6) 0.51 (0.51, 0.51)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.147 (0.147, 0.147) NA (NA, NA) 0.113 (0.113, 0.113) 0.066 (0.066, 0.066) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.396 (0.396, 0.396) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 3 (3, 3) 0 (0, 0) 8 (8, 8) 2 (2, 2) 1 (1, 1) 2 (2, 2) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 5 (5, 5) 0 (0, 0) 0 (0, 0) 1 (1, 1) 4 (4, 4) 0 (0, 0)
post_p 0.56 (0.56, 0.56) NA (NA, NA) 0.65 (0.65, 0.65) 0.55 (0.55, 0.55) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.63 (0.63, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) NA (NA, NA) 0.069 (0.069, 0.069) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.069 (0.069, 0.069) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
TP53- & AR- Hormone_therapies count 240 240 240 240
time 13 (9, 29) 13 (9, 29) 13 (9, 29) 13 (9, 29)
n 21 (15, 52) 4 (2, 12) 4 (2, 11) 4 (1, 13)
post_p 0.96 (0.83, 1) 0.63 (0.53, 0.87) 0.61 (0.52, 0.81) 0.56 (0.51, 0.76)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.039 (0.018, 0.062) 0.024 (0, 0.071) 0.017 (0, 0.068) 0 (0, 0.047)
Niraparib count 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 19 (19, 19) 3 (3, 3) 2 (2, 2) 1 (1, 1)
post_p 0.83 (0.83, 0.83) 0.75 (0.75, 0.75) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.055 (0.055, 0.055) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 10 (10, 10) 9 (9, 9) 2 (2, 2) 2 (2, 2) 1 (1, 1) 2 (2, 2) 1 (1, 1) 2 (2, 2)
post_p 0.73 (0.73, 0.73) 0.74 (0.74, 0.74) 0.52 (0.52, 0.52) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.093 (0.093, 0.093) 0.042 (0.042, 0.042) 0 (0, 0) 0.257 (0.257, 0.257) 0 (0, 0) 0.29 (0.29, 0.29) 1.078 (1.078, 1.078) 0 (0, 0)
Taxel_therapies count 16 16 16 16 16 16 16 16
time 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18) 11 (8, 18)
n 11 (7, 20) 8 (4, 12) 1 (0, 4) 2 (0, 6) 3 (2, 7) 3 (1, 6) 2 (0, 4) 3 (0, 5)
post_p 0.77 (0.7, 0.86) 0.85 (0.71, 0.96) 0.53 (0.51, 0.63) 0.54 (0.52, 0.74) 0.64 (0.54, 0.8) 0.62 (0.54, 0.95) 0.55 (0.51, 0.66) 0.55 (0.52, 0.6)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.086 (0.057, 0.133) 0.021 (0, 0.055) 0 (0, 0.093) 0 (0, 0.083) 0.087 (0, 0.145) 0 (0, 0.04) 0 (0, 0.126) 0 (0, 0.037)
Carboplatin count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 7 (7, 7) 5 (5, 5) 3 (3, 3) 2 (2, 2) 2 (2, 2) 2 (2, 2) 3 (3, 3) 2 (2, 2)
post_p 0.81 (0.81, 0.81) 0.55 (0.55, 0.55) 0.74 (0.74, 0.74) 0.53 (0.53, 0.53) 0.68 (0.68, 0.68) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) 0.56 (0.56, 0.56)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.074, 0.074) 0.043 (0.043, 0.043) 0 (0, 0) 0 (0, 0) 0.109 (0.109, 0.109) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 8 (8, 8) 4 (4, 4) 5 (5, 5) 1 (1, 1) 2 (2, 2) 3 (3, 3) 2 (2, 2) 1 (1, 1)
post_p 0.96 (0.96, 0.96) 0.61 (0.61, 0.61) 0.74 (0.74, 0.74) 0.52 (0.52, 0.52) 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.057 (0.057, 0.057) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.218 (0.218, 0.218) 0.125 (0.125, 0.125) 0 (0, 0) 0 (0, 0)
DRD+ Taxel_therapies count 1 1 1 1 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 4 (4, 4) 5 (5, 5) 5 (5, 5) 3 (3, 3) 1 (1, 1) 4 (4, 4) 1 (1, 1) 3 (3, 3)
post_p 0.56 (0.56, 0.56) 0.55 (0.55, 0.55) 0.69 (0.69, 0.69) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52) 0.54 (0.54, 0.54) 0.64 (0.64, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.054, 0.054) 0.029 (0.029, 0.029) 0 (0, 0) 0.056 (0.056, 0.056) 0 (0, 0) 0.101 (0.101, 0.101) 0 (0, 0) 0.056 (0.056, 0.056)
Carboplatin count 120 120 120 120 120 120 120 120
time 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33)
n 6 (3, 16) 6 (3, 15) 4 (1, 9) 4 (1, 10) 4 (2, 8) 4 (2, 9) 5 (2, 10) 4 (2, 9)
post_p 0.73 (0.54, 0.95) 0.71 (0.52, 0.85) 0.73 (0.57, 0.94) 0.66 (0.53, 0.83) 0.75 (0.54, 0.93) 0.67 (0.53, 0.87) 0.78 (0.57, 0.96) 0.69 (0.53, 0.84)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.026 (0, 0.052) 0.026 (0, 0.048) 0.03 (0, 0.071) 0.021 (0, 0.057) 0.028 (0, 0.087) 0.021 (0, 0.067) 0.03 (0, 0.07) 0.022 (0, 0.062)
Niraparib count 132 132 132 132 132 132 132 132
time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
n 8 (3, 14) 5 (3, 16) 4 (2, 9) 4 (1, 9) 4 (2, 8) 4 (2, 8) 4 (2, 8) 4 (2, 8)
post_p 0.76 (0.55, 0.94) 0.71 (0.52, 0.82) 0.73 (0.55, 0.93) 0.64 (0.52, 0.87) 0.72 (0.53, 0.91) 0.65 (0.53, 0.88) 0.72 (0.58, 0.94) 0.64 (0.52, 0.85)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.026 (0, 0.056) 0.022 (0, 0.04) 0.029 (0, 0.071) 0.022 (0, 0.064) 0.029 (0, 0.08) 0.019 (0, 0.056) 0.029 (0, 0.074) 0.021 (0, 0.063)
TEfus+ Taxel_therapies count 163 163 163 163 163 163 163 163
time 15 (9, 31) 15 (9, 31) 15 (9, 31) 15 (9, 31) 15 (9, 31) 15 (9, 31) 15 (9, 31) 15 (9, 31)
n 5 (2, 12) 11 (6, 23) 4 (2, 13) 3 (1, 7) 4 (1, 10) 4 (2, 10) 3 (1, 7) 3 (1, 9)
post_p 0.69 (0.54, 0.9) 0.92 (0.75, 1) 0.58 (0.51, 0.78) 0.59 (0.52, 0.81) 0.74 (0.56, 0.96) 0.72 (0.54, 0.97) 0.59 (0.52, 0.82) 0.58 (0.52, 0.84)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.03 (0, 0.068) 0.034 (0, 0.059) 0.012 (0, 0.045) 0 (0, 0.056) 0.023 (0, 0.073) 0.037 (0, 0.087) 0.01 (0, 0.067) 0.016 (0, 0.074)
Niraparib count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 2 (2, 2) 5 (5, 5) 3 (3, 3) 4 (4, 4) 3 (3, 3) 3 (3, 3) 4 (4, 4) 2 (2, 2)
post_p 0.52 (0.52, 0.52) 0.69 (0.69, 0.69) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) 0.69 (0.69, 0.69) 0.59 (0.59, 0.59) 0.61 (0.61, 0.61) 0.62 (0.62, 0.62)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.041 (0.041, 0.041) 0 (0, 0) 0.045 (0.045, 0.045) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 10 (10, 10) 1 (1, 1) 5 (5, 5) 8 (8, 8) 5 (5, 5) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.38 (0.38, 0.38) 0.5 (0.5, 0.5) 0.45 (0.45, 0.45) 0.41 (0.41, 0.41) 0.49 (0.49, 0.49) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.47) NA (NA, NA) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.181 (0.181, 0.181) 0 (0, 0) 0.203 (0.203, 0.203) 0.217 (0.217, 0.217) 0.071 (0.071, 0.071) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.455 (0.455, 0.455) NA (NA, NA) 0 (0, 0) 0.32 (0.32, 0.32) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 6 (6, 6) 0 (0, 0) 6 (6, 6) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 3 (3, 3) 2 (2, 2) 1 (1, 1) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1)
post_p 0.29 (0.29, 0.29) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) 0.49 (0.49, 0.49) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.39 (0.39, 0.39) 0.43 (0.43, 0.43) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.281 (0.281, 0.281) NA (NA, NA) 0.153 (0.153, 0.153) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.695 (0.695, 0.695) 0.452 (0.452, 0.452) 1.037 (1.037, 1.037) 0.108 (0.108, 0.108) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TP53- & AR- Hormone_therapies count 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 20 (20, 20) 4 (4, 4) 0 (0, 0) 4 (4, 4)
post_p 0.37 (0.37, 0.37) 0.49 (0.49, 0.49) NA (NA, NA) 0.44 (0.44, 0.44)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.14 (0.14, 0.14) 0.109 (0.109, 0.109) NA (NA, NA) 0.067 (0.067, 0.067)
Taxel_therapies count 118 118 118 118
time 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27)
n 23 (16, 45) 4 (1, 8) 5 (2, 10) 4 (2, 8)
post_p 0.12 (0.01, 0.38) 0.47 (0.37, 0.5) 0.32 (0.08, 0.46) 0.46 (0.34, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.157 (0.121, 0.219) 0.081 (0.04, 0.16) 0.166 (0.084, 0.31) 0.058 (0.026, 0.141)
Carboplatin count 138 138 138 138
time 14 (9, 23) 14 (9, 23) 14 (9, 23) 14 (9, 23)
n 23 (16, 44) 5 (2, 10) 4 (2, 8) 5 (2, 10)
post_p 0.14 (0, 0.31) 0.33 (0.09, 0.46) 0.46 (0.36, 0.49) 0.44 (0.35, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.155 (0.119, 0.23) 0.169 (0.081, 0.419) 0.085 (0.041, 0.216) 0.053 (0.025, 0.129)
Niraparib count 119 119 119 119
time 13 (9, 20) 13 (9, 20) 13 (9, 20) 13 (9, 20)
n 22 (15, 37) 5 (2, 9) 4 (1, 8) 4 (2, 10)
post_p 0.2 (0.02, 0.39) 0.35 (0.17, 0.46) 0.45 (0.39, 0.49) 0.45 (0.37, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.153 (0.116, 0.217) 0.16 (0.085, 0.321) 0.085 (0.047, 0.234) 0.062 (0.031, 0.136)
TP53+ Hormone_therapies count 237 237 237 237 237 237 237 237
time 17 (9, 32) 17 (9, 32) 17 (9, 32) 17 (9, 32) 17 (9, 32) 17 (9, 32) 17 (9, 32) 17 (9, 32)
n 16 (8, 33) 11 (6, 23) 3 (1, 7) 3 (1, 7) 4 (1, 9) 4 (1, 10) 3 (1, 7) 3 (1, 8)
post_p 0.34 (0.13, 0.48) 0.25 (0.04, 0.44) 0.4 (0.22, 0.48) 0.36 (0.15, 0.47) 0.39 (0.18, 0.49) 0.38 (0.13, 0.47) 0.4 (0.18, 0.47) 0.34 (0.09, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.18 (0.139, 0.256) 0.162 (0.115, 0.259) 0.177 (0.082, 0.426) 0.162 (0.077, 0.437) 0.213 (0.136, 0.525) 0.19 (0.114, 0.486) 0.189 (0.103, 0.544) 0.181 (0.077, 0.448)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 10 (10, 10) 9 (9, 9) 2 (2, 2) 0 (0, 0) 0 (0, 0) 2 (2, 2) 3 (3, 3) 3 (3, 3)
post_p 0.44 (0.44, 0.44) 0.4 (0.4, 0.4) 0.28 (0.28, 0.28) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) 0.17 (0.17, 0.17) 0.5 (0.5, 0.5)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.173 (0.173, 0.173) 0.142 (0.142, 0.142) 0.399 (0.399, 0.399) NA (NA, NA) NA (NA, NA) 0.08 (0.08, 0.08) 0.168 (0.168, 0.168) 0.134 (0.134, 0.134)
Niraparib count 4 4 4 4 4 4 4 4
time 11 (10, 16) 11 (10, 16) 11 (10, 16) 11 (10, 16) 11 (10, 16) 11 (10, 16) 11 (10, 16) 11 (10, 16)
n 13 (12, 14) 8 (4, 10) 2 (1, 4) 0 (0, 1) 4 (3, 6) 4 (2, 6) 1 (0, 3) 2 (1, 4)
post_p 0.33 (0.29, 0.39) 0.41 (0.13, 0.48) 0.45 (0.34, 0.49) 0.45 (0.42, 0.49) 0.44 (0.33, 0.48) 0.32 (0.14, 0.36) 0.48 (0.48, 0.49) 0.45 (0.42, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.207 (0.177, 0.255) 0.102 (0.081, 0.307) 0.129 (0.026, 0.187) 0.674 (0.135, 1.212) 0.206 (0.152, 0.244) 0.194 (0.132, 0.312) 0.064 (0.06, 0.069) 0.157 (0.066, 0.53)
DRD+ Hormone_therapies count 116 116 116 116 116 116 116 116
time 19 (13, 26) 19 (13, 26) 19 (13, 26) 19 (13, 26) 19 (13, 26) 19 (13, 26) 19 (13, 26) 19 (13, 26)
n 5 (2, 12) 5 (2, 11) 4 (2, 6) 3 (1, 7) 4 (2, 7) 4 (1, 7) 4 (1, 7) 3 (1, 7)
post_p 0.45 (0.3, 0.49) 0.43 (0.28, 0.49) 0.36 (0.2, 0.48) 0.34 (0.16, 0.46) 0.36 (0.16, 0.47) 0.34 (0.14, 0.45) 0.37 (0.16, 0.47) 0.35 (0.17, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.048, 0.158) 0.053 (0.032, 0.13) 0.183 (0.083, 0.426) 0.179 (0.088, 0.391) 0.178 (0.092, 0.471) 0.169 (0.1, 0.417) 0.186 (0.102, 0.577) 0.165 (0.075, 0.57)
Taxel_therapies count 10 10 10 10 10 10 10 10
time 16 (13, 24) 16 (13, 24) 16 (13, 24) 16 (13, 24) 16 (13, 24) 16 (13, 24) 16 (13, 24) 16 (13, 24)
n 8 (4, 10) 7 (2, 10) 4 (2, 6) 3 (1, 5) 5 (3, 7) 4 (2, 9) 4 (0, 8) 4 (2, 5)
post_p 0.22 (0.12, 0.47) 0.4 (0.29, 0.49) 0.4 (0.18, 0.47) 0.44 (0.37, 0.48) 0.34 (0.28, 0.48) 0.46 (0.41, 0.49) 0.33 (0.21, 0.4) 0.43 (0.3, 0.5)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.184 (0.093, 0.275) 0.082 (0.049, 0.162) 0.171 (0.153, 0.416) 0.067 (0.045, 0.184) 0.204 (0.095, 0.356) 0.08 (0.06, 0.193) 0.225 (0.164, 0.309) 0.094 (0.015, 0.142)
TEfus+ Hormone_therapies count 107 107 107 107 107 107 107 107
time 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33)
n 5 (2, 10) 10 (6, 18) 5 (2, 11) 3 (1, 7) 5 (2, 9) 4 (1, 8) 3 (1, 7) 3 (1, 7)
post_p 0.44 (0.31, 0.49) 0.21 (0.05, 0.44) 0.44 (0.31, 0.49) 0.37 (0.15, 0.45) 0.36 (0.15, 0.45) 0.38 (0.15, 0.48) 0.32 (0.12, 0.45) 0.35 (0.09, 0.45)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.091 (0.053, 0.223) 0.173 (0.118, 0.268) 0.054 (0.03, 0.131) 0.183 (0.09, 0.46) 0.189 (0.109, 0.39) 0.196 (0.101, 0.768) 0.177 (0.092, 0.421) 0.188 (0.088, 0.423)
Carboplatin count 14 14 14 14 14 14 14 14
time 16 (13, 28) 16 (13, 28) 16 (13, 28) 16 (13, 28) 16 (13, 28) 16 (13, 28) 16 (13, 28) 16 (13, 28)
n 5 (2, 11) 9 (5, 12) 5 (3, 9) 4 (0, 5) 4 (2, 8) 4 (2, 7) 3 (2, 7) 3 (1, 6)
post_p 0.24 (0.08, 0.41) 0.24 (0.15, 0.39) 0.46 (0.36, 0.48) 0.44 (0.27, 0.49) 0.39 (0.2, 0.48) 0.29 (0.09, 0.44) 0.45 (0.33, 0.47) 0.44 (0.39, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.205 (0.111, 0.358) 0.156 (0.097, 0.182) 0.044 (0.029, 0.113) 0.071 (0.032, 0.134) 0.137 (0.084, 0.376) 0.175 (0.117, 0.403) 0.104 (0.051, 0.165) 0.138 (0.04, 0.384)
Niraparib count 13 13 13 13 13 13 13 13
time 14 (12, 26) 14 (12, 26) 14 (12, 26) 14 (12, 26) 14 (12, 26) 14 (12, 26) 14 (12, 26) 14 (12, 26)
n 3 (3, 5) 11 (8, 24) 4 (2, 9) 3 (0, 4) 4 (2, 9) 5 (2, 9) 2 (0, 11) 3 (0, 5)
post_p 0.3 (0.13, 0.45) 0.12 (0.01, 0.32) 0.43 (0.27, 0.49) 0.44 (0.4, 0.48) 0.41 (0.24, 0.48) 0.39 (0.18, 0.46) 0.42 (0.36, 0.49) 0.42 (0.34, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.147 (0.094, 0.387) 0.164 (0.132, 0.255) 0.062 (0.044, 0.132) 0.065 (0.021, 0.256) 0.21 (0.144, 0.344) 0.206 (0.113, 0.261) 0.131 (0.079, 0.401) 0.118 (0.042, 0.653)